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1.2 Elements of Neuronal Dynamics

The effect of a spike on the postsynaptic neuron can be recorded with an intracellular electrode which measures the potential difference u(t) between the interior of the cell and its surroundings. This potential difference is called the membrane potential. Without any spike input, the neuron is at rest corresponding to a constant membrane potential. After the arrival of a spike, the potential changes and finally decays back to the resting potential, cf. Fig. 1.3A. If the change is positive, the synapse is said to be excitatory. If the change is negative, the synapse is inhibitory.

At rest, the cell membrane has already a strong negative polarization of about -65mV. An input at an excitatory synapse reduces the negative polarization of the membrane and is therefore called depolarizing. An input that increases the negative polarization of the membrane even further is called hyperpolarizing.

1.2.1 Postsynaptic Potentials

Let us formalize the above observation. We study the time course ui(t) of the membrane potential of neuron i. Before the input spike has arrived, we have ui(t) = urest. At t = 0 the presynaptic neuron j fires its spike. For t > 0, we see at the electrode a response of neuron i

ui(t) - urest = : $\displaystyle \epsilon_{{ij}}^{}$(t) . (1.1)

The right-hand side of Eq. (1.1) defines the postsynaptic potential (PSP). If the voltage difference ui(t) - urest is positive (negative) we have an excitatory (inhibitory) postsynaptic potential or short EPSP (IPSP). In Fig. 1.3A we have sketched the EPSP caused by the arrival of a spike from neuron j at an excitatory synapse of neuron i.

Figure 1.3: A postsynaptic neuron i receives input from two presynaptic neurons j = 1, 2. A. Each presynaptic spike evokes an excitatory postsynaptic potential (EPSP) that can be measured with an electrode as a potential difference ui(t) - urest. The time course of the EPSP caused by the spike of neuron j = 1 is $ \epsilon_{{i1}}^{}$(t - t1(f)). B. An input spike from a second presynaptic neuron j = 2 that arrives shortly after the spike from neuron j = 1, causes a second postsynaptic potential that adds to the first one. C. If ui(t) reaches the threshold $ \vartheta$, an action potential is triggered. As a consequence, the membrane potential starts a large positive pulse-like excursion (arrow). On the voltage scale of the graph, the peak of the pulse is out of bounds. After the pulse the voltage returns to a value below the resting potential.
{\bf A}

1.2.2 Firing Threshold and Action Potential

Consider two presynaptic neurons j = 1, 2, which both send spikes to the postsynaptic neuron i. Neuron j = 1 fires spikes at t1(1), t1(2),..., similarly neuron j = 2 fires at t2(1), t2(2),.... Each spike evokes a postsynaptic potential $ \epsilon_{{i1}}^{}$ or $ \epsilon_{{i2}}^{}$, respectively. As long as there are only few input spikes, the total change of the potential is approximately the sum of the individual PSPs,

ui(t) = $\displaystyle \sum_{j}^{}$$\displaystyle \sum_{f}^{}$$\displaystyle \epsilon_{{ij}}^{}$(t - tj(f)) + urest , (1.2)

i.e., the membrane potential responds linearly to input spikes; see Fig. 1.3B.

On the other hand, linearity breaks down if too many input spikes arrive during a short interval. As soon as the membrane potential reaches a critical value $ \vartheta$, its trajectory shows a behavior that is quite different from a simple summation of PSPs: The membrane potential exhibits a pulse-like excursion with an amplitude of about 100 mV, viz., an action potential. This action potential will propagate along the axon of neuron i to the synapses of other neurons. After the pulse the membrane potential does not directly return to the resting potential, but passes through a phase of hyperpolarization below the resting value. This hyperpolarization is called `spike-afterpotential'.

Single EPSPs have amplitudes in the range of one millivolt. The critical value for spike initiation is about 20 to 30 mV above the resting potential. In most neurons, four spikes - as shown schematically in Fig. 1.3C - are thus not sufficient to trigger an action potential. Instead, about 20-50 presynaptic spikes have to arrive within a short time window before postsynaptic action potentials are triggered.

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Next: 1.3 A Phenomenological Neuron Up: 1. Introduction Previous: 1.1 Elements of Neuronal
Gerstner and Kistler
Spiking Neuron Models. Single Neurons, Populations, Plasticity
Cambridge University Press, 2002

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